The Gamecocks (4-0, 2-0 Southeastern Conference) won on defense, holding the Commodores (3-1, 1-1) to 77 yards.
South Carolina is 4-0 for the first time in coach Steve Spurrier's seven years with the team.
But it was frustrating for the coach. Quarterback Stephen Garcia threw four interceptions.
Garcia did throw his third touchdown pass, as many as defensive end Melvin Ingram has now scored this season. Ingram recovered a teammate's fumble in the end zone to go with two sacks, a tackle for an 8-yard loss and swatted away a pass.